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9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester

UM729

CAS: 1448723-60-1

Molecular Formula: C20H25N5O2

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9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester - Names and Identifiers

Name UM729
Synonyms C07
UM729
UM 729
UM-729
CS-1240
methyl 4-(3-(piperidin-1-yl)propylamino)-9H-pyrimido[4,5-b]indole-7-carboxylate
4-[[3-(1-Piperidinyl)propyl]amino]-9H-pyrimido[4,5-b]indole-7-carboxylic acid methyl ester
9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester
CAS 1448723-60-1

9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester - Physico-chemical Properties

Molecular FormulaC20H25N5O2
Molar Mass367.44
In vitro studyum729 expands normal hematopoietic stem and progenitor cells (HSPC) in an AhR-independent manner, UM729 inhibits AML cell differentiation. In 05H163 cells, the addition of UM729 increased the number of CD34 cd15-cells compared to AhR inhibitors (flavonoids, benzothiophene, and β-carboline) alone. UM729 can be combined with AhR antagonists to inhibit most of the AML cell differentiation.
In vivo studyIn NSG mice, UM729 alone or in combination with SR1 increased engraftment but not leukemic stem cell (LSC) frequency distribution.

9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester - References

biological activity UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists.
Last Update：2024-04-09 20:52:54
9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester
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9H-Pyrimido[4,5-b]indole-7-carboxylic acid, 4-[[3-(1-piperidinyl)propyl]amino]-, methyl ester
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